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The characteristic features of MSA include both motor and autonomic disturbances including Parkinsonism, cerebellar ataxia, orthostatic hypotension, urinary dysfunction and cardiovascular issues which often has fatal consequences ( Most of the PD cases are linked to late adult onset and are sporadic in nature

However, CBN exhibited a significantly lower potency than THC, per the differences in their relative binding affinity for CB1 receptors (K i

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10.1155/2016/7891574 164 Wang HH.GeX.QuH.WangN.ZhouJ.XuW.et al (2020).

The criterion for placing a drug in C-I is because it poses a significant risk of abuse and dependence and has no approved medical use